#soylent | Logs for 2020-02-22

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[01:35:44] <Bender> [SoylentNews] - Facebook Owes $9B in Taxes Related to Ireland Deal, IRS Says - https://sylnt.us - time-to-pay-the-piper
[01:46:38] -!- AzumaHazuki [AzumaHazuki!~hazuki@the.end.of.time] has joined #soylent
[02:03:37] * TheMightyBuzzard yawns
[02:03:37] * MrPlow flips a Skittle into TheMightyBuzzard's gaping mouth
[02:24:19] <AzumaHazuki> =submit https://www.theguardian.com from the genetic-algorithms? dept.
[02:24:23] <systemd> Submitting "Powerful antibiotic discovered using machine learning for first time"...( 1 modified urls; http://www.theguardian.com )
[02:24:44] <systemd> ✓ Sub-ccess! "03Powerful Antibiotic Discovered Using Machine Learning for First Time" (1 paragraphs) -> https://soylentnews.org
[02:25:44] <AzumaHazuki> THIS is what AI is for. if there were ever a case for using massive, parallelized brute force search algorithms, this is it
[02:30:12] <chromas> and also generating porn
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[02:40:09] <AzumaHazuki> chromas, come on now. maybe i'm biased as a pharmacy tech, but antibiotic resistance is a huge freaking problem and we need new ones like yesterday
[02:40:37] <chromas> I don't disagree at all
[02:40:43] <AzumaHazuki> not to mention, a lot of the ones we do have are frankly horrific. i cringe every time i see a systemic quinolone script (*floxacin) for example.
[02:40:50] <chromas> Does folding@home contribute to antibiotics at all?
[02:41:34] <AzumaHazuki> maybe indirectly?
[02:42:44] <AzumaHazuki> antibiotics attack the production of the cell wall (beta-lactams), protein synthesis (macrolides at S50 ribosomal subunit and aminoglycosides at S30 IIRC), or DNA synthesus (quinolones at topoisomerase 4 or gyrase)
[02:43:24] <AzumaHazuki> so maybe a folding@home sequence that tracks mutations in something like the porin or efflux-pump proteins might help
[02:44:09] * Bytram had a close call a couple years ago that had me in the hospital for nearly a week being pumped up with IVs of unisol(sp?) and of vancomycin -- last ditch antibiotics.
[02:44:52] <AzumaHazuki> Unisol doesn't sound familiar to me, but...linezolid maybe?
[02:45:02] <AzumaHazuki> though iirc that's usually oral rather than parenteral...
[02:45:14] * Bytram should add that 3 days in the infection started getting *worse*, so they had to crank up the dosages even more.
[02:45:25] <Bytram> nope. Uni-sometihg...
[02:45:27] <Bytram> brb
[02:48:08] <Bytram> I was kinda sorta close: Ampicillin/sulbactam "Unasyn"
[02:48:44] <Bytram> https://en.wikipedia.org
[02:48:45] <systemd> ^ 03Ampicillin/sulbactam - Wikipedia
[02:48:58] <AzumaHazuki> Oh, this one
[02:49:08] <AzumaHazuki> sulbactam is a beta-lactamase inhibitor
[02:50:03] <TheMightyBuzzard> fuck beta!
[02:50:42] <AzumaHazuki> that weird square-shaped moiety with the double-bonded oxygen is the "beta-lactam," lactam being a cyclic amide and beta meaning 4 membered (alphas have 3, gammas have 5, etc)
[02:50:57] <AzumaHazuki> if you cut one of these through hydrolosis, you get a beta-amino acid
[02:51:15] <AzumaHazuki> ...and stuff like this is why no one believes i did earth science in college :v
[02:51:57] <TheMightyBuzzard> i did computer programming but i still know how to make lots of things that blow up.
[02:52:03] <Bytram> I look at the skeletal forms of the elements in Unasyn and think that's kinda complicated... I'm glad they found it... and then I take a look at Vancomycin and my head just explodes! ( https://en.wikipedia.org )
[02:52:04] <systemd> ^ 03Vancomycin - Wikipedia
[02:52:47] <AzumaHazuki> yeah, vancomycin is nuts. so are macrolides
[02:53:26] <AzumaHazuki> as complicated as the beta-lactams are, you know to at least always look for the funny square under enough steric strain you can practically hear it going "hnnnnngh"
[02:54:09] * TheMightyBuzzard mourns the death of comedy
[02:54:52] <Bytram> How *did* they even discover vancomycin? Did someone have an infection when on some trip in the jungle, rubbed some mud on it and instead of it just feeling cooler, it suddenly started clearing up, too?
[02:55:29] <AzumaHazuki> according to Ye Pfft! of All Knowledge... https://en.wikipedia.org
[02:55:30] <systemd> ^ 03Vancomycin - Wikipedia ( https://en.wikipedia.org )
[02:55:43] <Bytram> AzumaHazuki: That almost sounds like something that Derek Lowe would write!!
[02:56:10] <AzumaHazuki> i love his blog so much
[02:56:27] <AzumaHazuki> he seems like a genuinely good man, on top of being seriously seriously smart
[02:56:57] <Bytram> And has the absolutely most amazing sense of humor!
[02:57:07] <AzumaHazuki> not coincidentally, he works as a drug discovery chemist, though his best stuff is when he dunks on all the high-nitration wonks at the Klapotke lab
[02:57:32] <Bytram> Oh do you ever have that right!
[02:57:53] <AzumaHazuki> someone joked that his chemical analysis program won't print some of those molecules because it keeps running out of Ns, LOL
[02:58:26] <Bytram> You see all those nitrogens over there/ Of course the only thing they would like even better is to have even more of them join in (or words to that effect...)
[02:58:31] <Bytram> ROFL!
[02:58:59] <AzumaHazuki> hexanitroisoazowurtzitane
[02:59:01] <Bytram> I thnk that was a reference to the one umm. wurtz
[02:59:09] <Bytram> yeah!
[02:59:37] <Bytram> =g hexanitroisoazowurtzitane lowe derek
[02:59:37] <systemd> https://www.baseball-reference.com - Derek Lowe Stats | Baseball-Reference.com
[02:59:44] <Bytram> huh?
[02:59:48] <AzumaHazuki> i didn't know what a wurtzitane compound was aside from the "saturated hydrocarbon" part from -tane...oh, and the "probably a military explosive" from the hexanitro part
[03:00:10] <AzumaHazuki> looking at that molecule got an audible "holy shit, what" from me
[03:00:19] <Bytram> =g hexanitroisoazowurtzitane "Derek Lowe" things i won't work with
[03:00:20] <systemd> [0 results]
[03:00:27] <Bytram> Huh!
[03:00:40] <Bytram> =g wurtzitane "Derek Lowe" things i won't work with
[03:00:41] <systemd> https://blogs.sciencemag.org - Things I Won't Work With: Hexanitrohexaazaisowurtzitane | In the ...
[03:00:52] <AzumaHazuki> forgot a hexa, LOL
[03:01:13] <Bytram> no biggee, really, there were already plenty of N's in there already!
[03:01:55] <AzumaHazuki> My thought process was "Okay, don't know what wurtz means...itane implies a saturated alkane. hexanitro means big boom. hexa-aza mean...jeez, it means this shouldn't even exist. don't tell me the nitros are bonded *to* the azos..."
[03:02:05] <Bytram> i was amazed that I even remembered the wurtz parts of it. (Last chem I took was in High School some cough cough decades ago)
[03:03:07] <AzumaHazuki> i think the fact that making a 1:1 cocrystal with TNT makes it more stable is the best/worst part of this
[03:08:18] <Bytram> What I find so fascinating is his writing style is so engaging and disarming, and he is so knowledgeable about all this, that he can describe these things using proper chemical names, and even I, decades since my last chem class can pretty much follow right along with, if not the gory details, at least the general idea. That skill in communication is exceedingly rare!
[03:08:49] <AzumaHazuki> Yeah...that's something that draws me into his writing. I've been able to do that on a much smaller scale with people too
[03:09:11] <Bytram> The only other place I've seen such skill in ... descriptions of ... "untoward" situations was in "Ignition!"
[03:09:21] <AzumaHazuki> back in the bad old days as "hey there's a chick in Geek Squad" they had me selling a lot too, and i did well with older customers for this reason
[03:09:22] <Bytram> =g Ignition!
[03:09:23] <systemd> https://www.ignitioncasino.eu - Ignition Casino: Play Blackjack, Slots, Poker, Texas hold'em and More
[03:09:36] <Bytram> =g Ignition! rocket
[03:09:37] <systemd> https://www.amazon.com - Ignition!: An Informal History of Liquid Rocket Propellants (Rutgers ...
[03:09:51] <AzumaHazuki> they pretty much all said i took the fear out of the process and explained things in ways that made sense. though getting some of the men to talk to me was like pulling teeth
[03:11:05] <Bytram> ^^^ that's the one. A few years back when it had been out of print for decades, I had it mentioned to me and that a search of the web could probably locate a pdf of scanned images of each of the pages.
[03:11:16] <Bytram> nodnod
[03:11:44] <Bytram> "meet 'em where they are at' is a very good way to get things going.
[03:12:03] <AzumaHazuki> plus, most things that don't actually need a PhD to understand can be explained on normal terms
[03:12:51] <AzumaHazuki> the analogy i used is that the CPU power is something like IQ ("how smart the machine is when it thinks about things"), working memory is "how much it can think about at one time," and drive space is "how big is its file cabinet"
[03:13:38] <Bytram> not so much the mega giga turbo ultra stuff, but what it actually means when using the computer... if your hard disk is too small, it's like having an attic that can only store a few boxes... then you have to start tossing things away.
[03:14:09] <AzumaHazuki> right
[03:14:11] <Bytram> for me, ram is kind of like the size of my desk.
[03:14:26] <Bytram> disk space is what is in my filing cabinets
[03:14:32] <AzumaHazuki> yes :)
[03:15:43] <AzumaHazuki> lol, explaining advanced data recovery was a fun one. "Imagine a city where you have to look in the phone book if you want to know who anyone is. Your phone book, the "master file table," is gone. So we've got a sort of detective who goes door to door, one door at a time, and asks people who they are, then rewrites the phone book elsewhere"
[03:15:58] <Bytram> and *I* am the cpu... to make a car analogy... some days I'm like a 17,000 RPM 4-cylinder Formula 1 race car engine... and other days, I more like a big 'ol v-12 diesel.
[03:16:29] <Bytram> I like that!
[03:16:58] <AzumaHazuki> this is "block carving." Like photorec and stuff, where it reads block by block and tries to figure out what the heck a file is by its magic numbers
[03:17:15] <Bytram> and... not to break this up... but I would like to get to bed at a reasonable hour tonight...
[03:17:42] <AzumaHazuki> LOL. Sleep well :)
[03:17:57] <Bytram> or like gathering pieces of shredded documents and reassembling the original from the parts..... which they CAN do, apparently!
[03:18:34] * Bytram much appreciated the chat... and a good night to you, as well!
[03:57:39] <Bender> [SoylentNews] - Facebook Offers to Pay Users for their Voice Recordings - https://sylnt.us - anything-for-a-buck
[04:23:25] <AzumaHazuki> ugh, i ate way too much this week...must have put a pound on easily ><
[04:23:47] <AzumaHazuki> if i were to pee on a pregnancy test right now, instead of a + or a - i'd get a little LCD slice of pizza
[04:46:38] <Cascade> !grab AzumaHazuki
[04:46:38] <Bender> Added quote 944
[06:28:26] <Bender> [SoylentNews] - Electric Bacteria Create Currents Out of Thin - and Thick - Air - https://sylnt.us - Lovley-Geobacter
[08:46:14] <Bender> [SoylentNews] - Microsoft Defender ATP Preview Arrives for Linux Distros -- iOS and Android Versions to Follow - https://sylnt.us - ATP-app-aptly-allays-APTs
[08:47:25] <chromas> Still waiting for Edge to come to Linux. Firefox and Chrome will finally have some competition.
[08:47:33] <chromas> Hm, wait a minute...
[08:47:38] <pinchy> least common denominator
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[09:14:19] <FatPhil> holy fuck, that zuzu line's hilarious!
[09:14:26] <FatPhil> AzumaHazuki++
[09:14:26] <Bender> karma - azumahazuki: 28
[09:16:40] <FatPhil> It's happening! S. Korea 433 +224
[09:19:54] <chromas> Are they playing Fütbol?
[09:24:58] <FatPhil> they're scoring more like basketball or cricket
[09:56:58] <chromas> Aha! nfs may have almost no security whatsoever, but I found one bit. If I upgrade the package without restarting the server then it thinks there's a host mismatch. Better than encryption or requiring credentials.
[10:02:43] <FatPhil> I just use SSHFS between home and office
[10:03:15] <FatPhil> I should probably set up a VPN, but I can't be arsed to work out how
[10:03:45] <chromas> Install NetworkManager :D
[10:04:09] <FatPhil> I like the transparency of always having the website under /net/webs/[domainname]/... no matter which machine I'm sitting at or logged into. I couldn't do without that.
[10:05:19] <FatPhil> likewise /net/media/Music/... is where all the mp3s are, I forget which building that even resides in now.
[10:05:42] <FatPhil> Is that some kind of RedHat or Ubuntu cancer?
[10:06:01] <chromas> RedHat I think. FreeDesktop anyhow
[10:06:02] <FatPhil> Or, worse, Windows or OSX?
[10:06:14] <FatPhil> Probably has Poettering sperm in it
[10:19:11] <chromas> "If you're assertions are correct (which I find astonishing) then find out who configured the server this way and shoot them before they can do any more harm."
[10:23:31] <FatPhil> If there grammar is to believed, agree;
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[10:35:24] <FatPhil> I shouldn't read the news, I just wind myself up.
[10:36:06] <FatPhil> For example, I'm absolutely seething with envy after reading: https://www.bbc.co.uk
[10:36:08] <systemd> ^ 03The remote island where jumpers are always in fashion
[10:36:59] <FatPhil> Tallinn has such a reputation for knitwear you can't get a good chunkyknit for less than about 75
[10:37:17] <FatPhil> So I can't bloody afford the clothing I want!
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[11:08:01] <Bender> [SoylentNews] - Kickstarter Workers Make History with Unionization Vote - https://sylnt.us - stick-together-or-fail-apart?
[13:14:42] <Bytram> coffee++
[13:14:42] <Bender> karma - coffee: 5112
[13:26:38] <Bender> [SoylentNews] - RIP: Larry Tesler, Inventor of Copy & Paste - https://sylnt.us - R.I.P.-R.I.P.-R.I.P.-R.I.P.-R.I.P.-...
[15:29:50] <Bytram> .op
[15:29:50] -!- mode/#soylent [+o Bytram] by Aphrodite
[15:29:59] <Bytram> .deop
[15:29:59] -!- mode/#soylent [-o Bytram] by Aphrodite
[15:45:22] <Bender> [SoylentNews] - Apple is Considering Letting Users Change Default Email, Browser, Music Apps in iOS - https://sylnt.us - took-them-long-enough
[16:32:54] <TheMightyBuzzard> .kick&nbsp;chromas
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[18:06:31] <Bytram> TheMightyBuzzard++ ROFL!
[18:06:31] <Bender> karma - themightybuzzard: 372
[18:15:07] <FatPhil> ITYM TheMightyBuzzard%2B%2B
[18:17:16] <Bender> [SoylentNews] - AT&T Loses Key Ruling in Class Action over Unlimited-Data Throttling - https://sylnt.us - forced-arbitration
[19:30:18] <chromas> Hm, who knew AAs with USB ports was a thing?
[19:30:22] <chromas> https://www.amazon.com
[19:46:52] <AzumaHazuki> that's very clever actually...a disposable cell is merely a chemical system known to generate so much current at such and such a voltage after all
[20:36:36] <Bender> [SoylentNews] - Let There be 'Circadian' Light - https://sylnt.us - Oh!-Now-I-see!
[22:21:56] <TheMightyBuzzard> yup, that's bloody brilliant. the triple As are the ones that really excite me though. i'd never have to buy remote batteries again if they can handle four digits of discharge cycles.
[22:45:30] <carny> i'm skeptical of consumer batteries that claim that kind of life span
[22:46:34] <carny> i wonder if you could replace them with an ultra capacitor though
[22:46:46] <carny> those would last a whole lot of cycles
[22:47:13] <carny> charge it up in a few seconds whenever it gets low enough to annoy you
[22:56:52] <Bender> [SoylentNews] - Quantum Interference Observed in Real Time: Extreme UV-Light Spectroscopy Technique - https://sylnt.us - for-your-viewing-pleasure
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